Analysis Approach Research Articles

Enhancing missing persons search strategies through technological touchpoints

ABSTRACT The search for the missing persons is a top priority for police, and technology is playing an increasingly important role in increasing the accuracy and rigour of these investigations. This study aims to increase understanding of police decision-making in the missing persons search process and to examine the desired point and level of technology participation from the user's perspective. Three empirical studies and workshops were conducted with police, UX researchers, and computer science researchers. During the workshops, participants developed diagrams to represent police work methods and difficulties and discussed how to identify optimal touch points for technology integration. The findings revealed that the uncertainty of information is the biggest challenge in missing persons search, and that closed-circuit television (CCTV) is a valuable tool. A comparative experiment was conducted to compare the CCTV utilisation investigation strategies of police experts and novices. Findings showed that experts are more efficient and effective in using CCTV to search for missing persons. Experts used their experiential knowledge to interpret information and judge the reliability of information more accurately than novices. Additionally, novices used strategies through rapid repetition of trial and error, while experts made decisions based on experience and intuition, but pursued decision-making based on explicit information. The study concludes by discussing technological approaches for information identification, analysis, and labour replacement in missing person investigations. Such approaches could help overcome the challenge of uncertainty and improve the overall efficiency and effectiveness of these investigations.

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

BACKGROUND The understanding of bile acid (BA) and unsaturated fatty acid (UFA) profiles, as well as their dysregulation, remains elusive in individuals with type 2 diabetes mellitus (T2DM) coexisting with non-alcoholic fatty liver disease (NAFLD). Investigating these metabolites could offer valuable insights into the pathophysiology of NAFLD in T2DM. AIM To identify potential metabolite biomarkers capable of distinguishing between NAFLD and T2DM. METHODS A training model was developed involving 399 participants, comprising 113 healthy controls (HCs), 134 individuals with T2DM without NAFLD, and 152 individuals with T2DM and NAFLD. External validation encompassed 172 participants. NAFLD patients were divided based on liver fibrosis scores. The analytical approach employed univariate testing, orthogonal partial least squares-discriminant analysis, logistic regression, receiver operating characteristic curve analysis, and decision curve analysis to pinpoint and assess the diagnostic value of serum biomarkers. RESULTS Compared to HCs, both T2DM and NAFLD groups exhibited diminished levels of specific BAs. In UFAs, particular acids exhibited a positive correlation with NAFLD risk in T2DM, while the ω-6:ω-3 UFA ratio demonstrated a negative correlation. Levels of α-linolenic acid and γ-linolenic acid were linked to significant liver fibrosis in NAFLD. The validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM patients. CONCLUSION This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM, proposing their potential as biomarkers in the pathogenesis of NAFLD.

Practice of breast self-examination and associated factors among women of reproductive age in the North Shoa Zone, Oromia, Ethiopia, 2022: a convergent mixed-methods study

ObjectiveTo assess practice of breast self-examination (BSE) and associated factors among women of reproductive age in the North Shoa Zone, Oromia, Ethiopia.DesignCommunity-based cross-sectional study with a convergent mixed-methods approach.SettingThe study...

V4RIN: visual analysis of regional industry network with domain knowledge.

The regional industry network (RIN) is a type of financial network derived from industry networks that possess the capability to describe the connections between specific industries within a particular region. For most investors and financial analysts lacking extensive experience, the decision-support information provided by industry networks may be too vague. Conversely, RINs express more detailed and specific industry connections both within and outside the region. As RIN analysis is domain-specific and current financial network analysis tools are designed for generalized analytical tasks and cannot be directly applied to RINs, new visual analysis approaches are needed to enhance information exploration efficiency. In this study, we collaborated with domain experts and proposed V4RIN, an interactive visualization analysis system that integrates predefined domain knowledge and data processing methods to support users in uploading custom data. Through multiple views in the system panel, users can comprehensively explore the structure, geographical distribution, and spatiotemporal variations of the RIN. Two case studies were conducted and a set of expert interviews with five domain experts to validate the usability and reliability of our system.

Sex/gender differences in general cognitive abilities: an investigation using the Leiter-3.

Research has shown that differences between males and females are not in general intelligence, but only in some specific factors and tasks. We used the Italian standardization of the Leiter-3, which is a completely nonverbal cognitive battery, to investigate the nature of sex/gender (we used sex/gender to reflect the awareness that the effects of biological 'sex' and socially constructed 'gender' cannot be easily separated and that most individuals' identities are informed by both sex and gender) differences. In doing so we used a multigroup confirmatory factor analysis approach. Results confirmed that males and females perform similarly in general intelligence, but present with some specificities. Males perform better on some, but not all, tasks requiring the spatial manipulation of the stimuli, but females consistently outperform males in tasks such as the nonverbal Stroop, requiring inhibition and attention control to a larger extent. The clinical and practical implications of our findings are considerable. The identification of specific cognitive strengths and weaknesses in males and females underscores the importance of tailored approaches in clinical assessments and interventions.

Optimization of treatment workflow for 0.35T MR-Linac system.

This study presents a novel and comprehensive framework for evaluating magnetic resonance guided radiotherapy (MRgRT) workflow by integrating the Failure Modes and Effects Analysis (FMEA) approach with Time-Driven Activity-Based Costing (TDABC). We assess the workflow for safety, quality, and economic implications, providing a holistic understanding of the MRgRT implementation. The aim is to offer valuable insights to healthcare practitioners and administrators, facilitating informed decision-making regarding the 0.35T MRIdian MR-Linac system's clinical workflow. For FMEA, a multidisciplinary team followed the TG-100 methodology to assess the MRgRT workflow's potential failure modes. Following the mitigation of primary failure modes and workflow optimization, a treatment process was established for TDABC analysis. The TDABC was applied to both MRgRT and computed tomography guided RT (CTgRT) for typical five-fraction stereotactic body RT (SBRT) treatments, assessing total workflow and costs associated between the two treatment workflows. A total of 279 failure modes were identified, with 31 categorized as high-risk, 55 as medium-risk, and the rest as low-risk. The top 20% risk priority numbers (RPN) were determined for each radiation oncology care team member. Total MRgRT and CTgRT costs were assessed. Implementing technological advancements, such as real-time multi leaf collimator (MLC) tracking with volumetric modulated arc therapy (VMAT), auto-segmentation, and increasing the Linac dose rate, led to significant cost savings for MRgRT. In this study, we integrated FMEA with TDABC to comprehensively evaluate the workflow and the associated costs of MRgRT compared to conventional CTgRT for five-fraction SBRT treatments. FMEA analysis identified critical failure modes, offering insights to enhance patient safety. TDABC analysis revealed that while MRgRT provides unique advantages, it may involve higher costs. Our findings underscore the importance of exploring cost-effective strategies and key technological advancements to ensure the widespread adoption and financial sustainability of MRgRT in clinical practice.

Participants' views of ultra-low dose combination therapy for high blood pressure: a mixed-methods study from the QUARTET trial.

Single-pill combination therapy containing four quarter-dose medications for high blood pressure improves BP control compared to monotherapy, however patient-reported acceptance of the quadpill as a treatment strategy remains undescribed. We collected within-trial feedback and interviewed participants from the quadruple ultra-low-dose treatment for hypertension (QUARTET) trial to characterise patient attitudes to this intervention. All trial participants were asked about ease and preference for the quadpill and provided an opportunity to give further comments on the trial at 12 weeks (trial primary endpoint) and 52 weeks extended follow-up. Separately, we used purposive and quota sampling for the semi-structured telephone interviews, with the resultant verbatim transcripts analysed using an inductive thematic analysis approach. Themes were re-evaluated after each successive interview, and at suspected data saturation, an additional interview conducted for confirmation. At 12 weeks follow-up, 502 of 591 (85%) participants responded to acceptability questions, and 359 of 417 (86%) responded at week 52. Most reported the trial capsule easy or very easy to take. From eight sites, 16 participants were interviewed between 5 August 2020 and 19 November 2020. All described a positive experience, preferred once-daily morning dosing and found routine facilitated adherence. Participants valued individual responsibility for adherence, and involvement of the general practitioner in blood-pressure management. Most reported capsule size did not deter adherence but desired a smaller capsule. Participants described a preference for minimising number and dosage of medications, reduced capsule size, and once-daily morning dosing. These findings suggest a preference for single-pill combination therapy for blood pressure lowering.

A Multimodal Sentiment Analysis Approach Based on a Joint Chained Interactive Attention Mechanism

A Multimodal Sentiment Analysis Approach Based on a Joint Chained Interactive Attention Mechanism

Who to engage in HIV vaccine trial benefit-sharing negotiations? An empirical proposition of a framework

BackgroundA morally sound framework for benefit-sharing is crucial to minimize research exploitation for research conducted in developing countries. However, in practice, it remains uncertain which stakeholders should be involved in the decision-making process regarding benefit-sharing and what the implications might be. Therefore the study aimed to empirically propose a framework for benefit-sharing negotiations in research by taking HIV vaccine trials as a case.MethodsThe study was conducted in Tanzania using a case study design and qualitative approaches. Data were collected using in-depth interviews (IDI) and focus group discussions (FGD). A total of 37 study participants were selected purposively comprising institutional review board (IRB) members, researchers, community advisory board (CAB) members, a policymaker, and HIV/AIDS advocates. Deductive and inductive thematic analysis approaches were deployed to analyze collected data with the aid of MAXQDA version 20.4.0 software.ResultsThe findings indicate a triangular relationship between the research community, researched community and intermediaries. However, the relationship ought to take into consideration the timing of negotiations, the level of understanding between parties and the phase of the clinical trial. The proposed framework operationalize partnership interactions in community-based participatory research.ConclusionIn the context of this study, the suggested framework incorporates the research community, the community being researched, and intermediary parties. The framework would guarantee well-informed and inclusive decision-making regarding benefit-sharing in HIV vaccine trials and other health-related research conducted in resource-limited settings.

Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was applied to image retinal and choroidal BF using custom-made dual eye coils that could image both eyes during the same scan. Statistics using data from a single eye or two eyes were compared. BF values were calculated using two approaches. The BF rate per quantity of tissue was calculated as commonly done, and the peak BF values of the retinal and choroidal vasculatures were taken. Additionally, the BF rate per retinal surface area was calculated using a new analysis approach to attempt to reduce partial volume and variability by integrating BF over the retinal and choroidal depths.ResultsOcular BF of both eyes could be imaged using the dual coil setup without effecting scan time. Intraocular pressure was significantly elevated in DBA/2J mice compared to C57BL/6J mice (P<0.01). Both retinal and choroidal BF were significantly decreased in DBA/2J mice in comparison to the age-matched normal C57BL/6J mice across all measurements (P < 0.01). From simulations, the values from the integrated BF analysis method had less partial volume effect, and from in vivo scans, this analysis approach also improved power.ConclusionThe dual eye coil setup allows bilateral eye data acquisition, increasing the amount of data acquired without increasing acquisition times in vivo. The reduced ocular BF found using the improved acquisition and analysis approaches replicated the results of previous studies on DBA/2J mice. The ocular hypertensive stress-induced BF reduction found within these mice may represent changes associated with glaucomatous progression.

An integrated experimental and analytical approach on mechanical characterization of advanced powder metallurgy aluminium metal matrix composites reinforced with different particulates

Abstract Over the last few decades, “Discontinuously Reinforced Particulate Composites (DRPCs)” are a popular class of composite materials with considerable challenge in processing, characterization and machinability because of their increased strength-weight ratio, stiffness, specific strength and oxidization when compared to various metals and their alloys. This paper discusses experimental and numerical investigation on mechanical characteristics of aluminum metal matrix reinforced with various reinforcement particulates such as silicon carbide, aluminium oxide, and zirconium oxide, compaction pressure (kN) and hold time (s) based on Design of Experiments (DOE) and Finite Element Analysis. Initially this paper discusses the process optimization of Aluminum Matrix reinforced with different particulates experimentally to identify the favourable processing conditions by varying reinforcement materials, compaction pressure (kN) and hold time (s) based on TDOE (Taguchi’s Design of Experiments). Further, this paper concentrates to determine “maximum principal stress, equivalent elastic strain and equivalent (von-mises) stress” based on Finite Element Analysis (ANSYS Workbench-2023R1). The results of the experimentation showed that the highest hardness values were achieved with ZrO2 reinforcement material. Increasing the compaction pressure from 8 to 12 kN resulted in a slight decrease in surface roughness and porosity. Higher compaction pressures have assumed to facilitate better particle distribution and improved interfacial bonding, leading to smoother surfaces and lower void content. The simulation results showed that the maximum principal stress achieved were (2235.8 Mpa) SiC, (3444.4 Mpa) Al2O3, and (3582.5 MPa) ZrO2. The equivalent elastic strain achieved was (0.2488) SiC, (0.2421) Al2O3 and (0.262) ZrO2. The equivalent (Von Mises) stress achieved was (28751 MPa) for SiC, (24880 MPa) for ZrO2 and (26972 Mpa) for Al2O3. This experimentation and simulation demonstrated that the PM process can be used to fabricate DRAMMC with different reinforcement particulates.

The protocol for a cluster randomized controlled trial to evaluate couple-based violence prevention education and its ability to reduce intimate partner violence during pregnancy in Southwest Ethiopia.

A significant proportion of women in Ethiopia suffer from violence by their intimate partner during pregnancy, which has adverse maternal and newborn outcomes. Couple-focused interventions are effective in reducing and/or controlling violence between women and their intimate partners. However, interventions addressing intimate partners of the victims are not well studied, particularly in the Ethiopian setting. This study aims to assess the effect of couple-based violence prevention education on intimate partner violence during pregnancy. We will use a cluster randomized controlled trial to evaluate the effectiveness of couple-based violence prevention education compared to routine care in reducing intimate partner violence during pregnancy. Sixteen kebeles will be randomly assigned to 8 interventions and 8 control groups. In the trial, 432 couples whose wife is pregnant will participate. Health extension workers (HEWs) will provide health education. Data will be collected at baseline and endline. All the collected data will be analyzed using Stata version 16.0 or SPSS version 25.0. We will use the McNemar test to assess the differences in outcomes of interest in both intervention and control groups before and after the intervention for categorical data. A paired t-test will be used to compare continuous outcome of interest in the intervention and the control groups after and before the intervention. The GEE (Generalized Estimating Equation), will be used to test the independent effect of the intervention on the outcome of the interest. Data analysis will be performed with an intention-to-treat analysis approach. During the analysis, the effect size, confidence interval, and p-value will be calculated. All tests will be two-sided, and statistical significance will be declared at p < 0.05. We expect that the study will generate findings that can illuminate violence prevention strategies and practices in Ethiopia. It has been registered on ClinicalTrials.gov as NCT05856214 on May 4, 2023.

Is the Tendon-to-Groove Ratio Associated with Elevated Risk for LHB Tendon Disorders?—A New Approach of Preoperative MR-Graphic Analysis for Targeted Diagnosis of Tendinopathy of the Long Head of Biceps

Background: Pathologies of the long head of the biceps (LHB) tendon are a common cause of anterior shoulder pain. While the influence of the anatomical morphology of the intertubercular groove (ITG) on the development of LHB tendon instability has been investigated with ambiguous results, the relationship of the LHB to ITG anatomy has not yet been considered in this context. The objective of this study was to reliably extract the tendon-to-groove ratio from MRI scans of symptomatic patients and examine its potential influence on the occurrence of certain causes for LHB-associated symptoms. Methods: In this retrospective study, preoperative MRI scans of 35 patients (mean age of 46 ± 14 years) presenting with anterior shoulder pain and clinical indications of LHB tendinopathy were analyzed in transversal planes. Long and short diameters of the LHB tendon and ITG were measured, cross-sectional areas of the LHB tendon and ITG were calculated from these measurements, and the ratio of cross-sectional areas (LHB/ITG) was introduced. All measurements were repeated independently by three investigators and inter-rater reliability was assessed using intraclass correlation coefficient (ICC). Thereafter, tendon-to-groove ratios were compared in patients with and without intraoperative signs of LHB tendon instability. Results: All patients exhibited intraoperative signs of LHB tendinitis, with additional findings including pulley lesions and SLAP lesions. Analysis revealed variations in the dimensions of the LHB tendon and ITG cross sections, with the tendon-to-groove ratio decreasing from 37% at the pulley to 31% at the deepest point of the sulcus. Very good inter-rater reliability was observed for all measurements. The tendon-to-groove ratio did not significantly differ (p &gt; 0.05) in patients with or without pulley lesions or SLAP lesions. Conclusions: Our study introduced the novel parameter of the tendon-to-groove ratio of cross-sectional areas as a reproducible parameter for the description of local anatomy in the field of targeted diagnosis of LHB tendon disorders. While our findings do not yet support the predictive value of the tendon-to-groove ratio, they underscore the importance of further research with larger cohorts and control groups to validate these observations.

Translanguaging in a beauty salon

Abstract This is an explanatory case study of how translanguaging offers space for practicing two shared languages: Saudi Pidgin Arabic and English as a lingua franca (ELF). It attends closely to overt types of translanguaging resources practiced by interlocutors. The study utilizes the conversation analysis (CA) approach to analyze conversations totaling 240 minutes, held in a beauty salon, between a Saudi female client and a Filipino beautician who communicated with each other using English and Saudi pidgin. The results show that the speakers’ interaction is mainly in English, but they switch to pidgin Arabic to fix misunderstandings, create humor, and engage in cooperative interaction. The study demonstrates that overt translanguaging resources employed by participants strengthen the multilingual nature of their ELF interactions, during which another contact language–Saudi pidgin in this case–can be practiced as another lingua franca. The study extends the limited literature on the nature of translanguaging in lingua franca social contexts and demonstrates the uniqueness of the translanguaging resources employed by ELF users.

THE MONGOL EMPIRE AND KOREA: FROM WAR TO VASSALAGE

The purpose of the article is an in-depth analysis of the complex relationship between the Mongolian Empire and the Korean state from the period of military conflicts to the establishment of vassalage. The research is aimed at identifying the key factors determining the course and historical significance of these relations. The novelty of the study lies in an in-depth analysis of the numerous Mongol campaigns against Korea and the resistance of Korea. The main direction of the research is to study the impact of these events on the historical dynamics of the region and the development of society as a whole. Special attention is paid to the analysis of diplomatic and trade relations between the nomads of the Far East and Korea, as well as China's role in the fate of Korea as a traditional overlord. Despite the difficult times, the article emphasizes that Korea was able to maintain its autonomy and become a key hub on the Great Silk Road, which contributed to the development of handicraft production and increased its authority. The article represents an important contribution to historical science, enriching our understanding of the complex relationships in the Northeast Asian region. The practical significance of the article lies in the possibility of applying its results to a deeper analysis of modern geopolitical processes. The research methodology includes an analytical approach to data interpretation and a comparative analysis of historical events. The authors analyze the impact of the collapse of the clan system and the crisis of the central government on the military system of the Korean state, paying attention to changes in the mobilization system, which turned out to be one of the reasons for the deterioration of the political and social situation in the country. As a result of the research, the key factors determining the course of relations between the Mongolian Empire and the Korean state have been identified. The analysis allows us to conclude that these events are important for shaping the historical trajectory of both peoples and the region as a whole.

Stiffness of Loaded Face of Steel Rectangular Hollow Section Columns with and without Concrete Infill in Beam-column Endplate Connections

This paper presents a new analytical approach for calculating the stiffness of the loaded face of a rectangular hollow section RHS column in beam-column connections with and without concrete infill, as well as with flush and extended endplates, to determine the behavior curve of these types of connections. The approach, based on Eurocode 03's component method, offers efficient analytical formulas for accurately determining the loaded face's stiffness. A comparison with existing methods demonstrates its remarkable simplicity and efficiency, allowing a simple beam model to represent the RHS column's behavior with all relevant parameters considered. Comparison of the new approach to existing ones from the literature demonstrates their reliability and efficiency. Furthermore, when compared to 32 experimental tests presenting nearly the entire range of probable connection configurations, as well as attachment techniques commonly used in construction practice, the margin of error does not exceed 12 percent on average and a maximum of less than 25 percent.

Language Mindset, Anxiety, and Proficiency: What Does Path Analytic Approach Indicate?

Language Mindset, Anxiety, and Proficiency: What Does Path Analytic Approach Indicate?

The Entrepreneurial Content in the Industrial Design Curriculum in Southwest Nigeria: Textile Design Techniques and Trends

This paper explored the incorporation of entrepreneurial content in the industrial design curriculum in universities in Southwest Nigeria, with a specific focus on textile design. Acknowledging the landscape of the global textile industry and the cultural significance of textiles in Southwest Nigeria, the study examined the existing industrial design curriculum, highlighting the level of consideration given to entrepreneurship in the development of the curriculum. The study adopted the content analysis approach to investigate the entrepreneurial content of textile design in the industrial design curriculum. The industrial design curriculum of the Federal University of Technology, Akure (FUTA) was selected because FUTA is the only university offering the industrial design curriculum in the region. The curriculum was analyzed across all levels, the entrepreneurial courses were highlighted based on the course synopsis while other courses were classified as general courses. The study revealed that entrepreneurship was given good consideration during the development of the curriculum. It was therefore recommended that the curriculum be updated regularly to ensure it remains relevant and meets the entrepreneurial needs of the students.

'It helps you forget your worries': A pilot study exploring music therapy in the acute hospital aged care setting.

Few studies have explored music therapy (MT) in an acute aged care inpatient setting. We aimed to assess feasibility and patient/staff perceptions of an 8-week MT program on an acute geriatric ward. An 8-week in-person MT program, comprising brief receptive musical interventions up to twice-weekly. All patients admitted to the aged care ward were eligible for inclusion. A hard copy survey was used to assess patient and staff perceptions of MT. Themes raised in free-text responses were manually coded within a thematic analysis approach. A mixed methods approach was used to obtain and analyse data relating to feasibility and patient and staff perceptions of the MT intervention. The 8-week program ran to completion and was delivered to a median of 11 patients (IQR 9-12) each session (median 8 new/day). In total, 10 patients completed surveys, mean age 81.1 (SD 7.7); 60% were women and all had cognitive impairment. Following an MT session, eight of eight responding patients reported feeling happy and eight of eight reported they would recommend MT. Staff respondents (n = 19) reported patients appeared happy (19/19), relaxed (13/19) and all would recommend MT to other patients. Common themes were that MT was followed by improved patient behaviour and mood, and stimulated patients. An acute aged care inpatient MT program proves feasible and well-received by staff and patients. Future research may focus on more robust data collection in larger sample sizes, specific types of MT and more in-depth exploration of the patient and carer experiences.

Examining the Effects of Nutrient Supplementation on Metabolic Pathways via Mitochondrial Ferredoxin in Aging Ovaries

As women age, oocytes are susceptible to a myriad of dysfunctions, including mitochondrial dysfunction, impaired DNA repair mechanisms, epigenetic alterations, and metabolic disturbances, culminating in reduced fertility rates among older individuals. Ferredoxin (FDX) represents a highly conserved iron–sulfur (Fe–S) protein essential for electron transport across multiple metabolic pathways. Mammalian mitochondria house two distinct ferredoxins, FDX1 and FDX2, which share structural similarities and yet perform unique functions. In our investigation into the regulatory mechanisms governing ovarian aging, we employed a comprehensive multi-omics analysis approach, integrating spatial transcriptomics, single-cell RNA sequencing, human ovarian pathology, and clinical biopsy data. Previous studies have highlighted intricate interactions involving excessive lipid peroxide accumulation, redox-induced metal ion buildup, and alterations in cellular energy metabolism observed in aging cells. Through a multi-omics analysis, we observed a notable decline in the expression of the critical gene FDX1 as ovarian age progressed. This observation prompted speculation regarding FDX1’s potential as a promising biomarker for ovarian aging. Following this, we initiated a clinical trial involving 70 patients with aging ovaries. These patients were administered oral nutritional supplements consisting of DHEA, ubiquinol CoQ10, and Cleo-20 T3 for a period of two months to evaluate alterations in energy metabolism regulated by FDX1. Our results demonstrated a significant elevation in FDX1 levels among participants receiving nutritional supplementation. We hypothesize that these nutrients potentiate mitochondrial tricarboxylic acid cycle (TCA) activity or electron transport chain (ETC) efficiency, thereby augmenting FDX1 expression, an essential electron carrier in metabolic pathways, while concurrently mitigating lipid peroxide accumulation and cellular apoptosis. In summary, our findings underscore the potential of nutritional intervention to enhance in vitro fertilization outcomes in senescent cells by bolstering electron transport proteins, thus optimizing energy metabolism and improving oocyte quality in aging women.